㈠ 緋栫簿鏈夋瘨涓轟粈涔堥熷搧瀹夊叏娉曚腑涓嶇佹㈠姞緋栫簿
緋栫簿錛屼篃縐緋栫簿閽錛屾槸鏈鍙よ佺殑鐢滃懗鍓傘傜硸綺句簬1878騫磋緹庡浗縐戝﹀跺彂鐜幫紝寰堝揩灝辮椋熷搧宸ヤ笟鐣屽拰娑堣垂鑰呮帴鍙椼傜硸綺劇殑鐢滃害涓钄楃硸鐨300鍊嶅埌500鍊嶏紝瀹冧笉琚浜轟綋浠ｈ阿鍚告敹錛屽湪鍚勭嶉熷搧鐢熶駭榪囩▼涓閮藉緢紼沖畾錛岀己鐐規槸椋庡懗宸錛屾湁鍚庤嫤錛岃繖浣垮叾搴旂敤鍙楀埌涓瀹氶檺鍒躲傜硸綺炬湁寰堝氬勾閮芥槸涓栫晫涓婃儫涓澶ч噺鐢熶駭涓庝嬌鐢ㄧ殑鍚堟垚鐢滃懗鍓傦紝灝ゅ叾鏄鍦絎浜屾′笘鐣屽ぇ鎴鏈熼棿錛岀硸綺懼湪涓栫晫鍚勫浗鐨勪嬌鐢ㄦ槑鏄懼炲姞銆
緋栫簿鐨勫畨鍏ㄦт竴鐩村瓨鍦ㄤ簤璁銆
1958騫達紝緹庡浗椋熷搧鑽鍝佺＄悊灞(FDA)寮濮嬪椋熷搧娣誨姞鍓鐨勪嬌鐢ㄨ繘琛岀＄悊錛屽綋鏃剁硸綺懼凡緇忚兘澶熷湪緹庡浗騫挎硾浣跨敤浜嗭紝鍥犳ゅ畠琚鍒楀叆鏈鏃╃殑675縐嶁滃叕璁ゅ畨鍏ㄢ(GRAS)鐨勯熷搧鍘熸枡鍚嶅崟涔嬩腑銆
1972騫達紝緹庡浗FDA鏍規嵁涓欏歸暱鏈熷ぇ榧犲杺鍏誨疄楠岀殑緇撴灉鍐沖畾鍙栨秷緋栫簿鐨勨滃叕璁ゅ畨鍏ㄢ濊祫鏍箋
1977騫達紝鍔犳嬁澶х殑涓欏瑰氫唬澶ч紶鍠傚吇瀹為獙鍙戠幇錛屽ぇ閲忕殑緋栫簿鍙瀵艱嚧闆勬уぇ榧鑶鑳辯檶銆備負姝わ紝緹庡浗FDA鎻愯紱佹浣跨敤緋栫簿錛屼絾榪欓」鍐沖畾閬鍒板浗浼氬弽瀵癸紝騫墮氳繃涓欏硅妗堝歡緙撶佺敤銆
1991騫達紝緹庡浗FDA鏍規嵁涓浜涚爺絀剁粨鏋滄挙鍥炰簡紱佹㈢硸綺句嬌鐢ㄧ殑鎻愯銆備絾鐢變簬涓婅堪鍘熷洜錛屽湪緹庡浗浣跨敤緋栫簿浠嶉渶鍦ㄦ爣絳句笂娉ㄦ槑鈥滀嬌鐢ㄦ湰浜у搧鍙鑳藉瑰仴搴鋒湁瀹籌紝鏈浜у搧鍚鏈夊彲浠ュ艱嚧瀹為獙鍔ㄧ墿鐧岀梲鐨勭硸綺鋸濄
鍦ㄥ浗闄呬笂錛岀硸綺劇殑浣跨敤涔熷洜涓鴻繖浜涘叧浜庡ぇ榧犺嚧鐧岀殑鐮旂┒鍙戣〃鍚庡彈鍒頒竴瀹氬獎鍝嶏紝嬈х編鍥藉剁硸綺劇殑浣跨敤閲忎笉鏂鍑忓皯銆備絾浠嶆湁浜烘寔涓嶅悓瑙傜偣錛岃や負緋栫簿鏄瀹夊叏鐨勩
鎴戝浗鏀垮簻涔熼噰鍙栧帇鍑忕硸綺炬斂絳栵紝騫惰勫畾涓嶅厑璁稿湪濠村効椋熷搧涓浣跨敤銆傜洰鍓岼ECFA瑙勫畾緋栫簿鐨凙DI鍊間負姣忔棩0-5mg/kg浣撻噸銆備互涓婁緵鍙傝冦